Fibroblast subtypes alter the microenvironment

Charged anaesthetics alter LM-fibroblast plasma-membrane

The functional consequences of the differences in lipid composition and structure between the two leaflets ofthe plasma membrane were investigated. Fluorescence of 1,6-diphenylhexa1,3,5-triene (DPH), quenching, and differential polarized phase fluorimetry demonstrated selective fluidization by local anaesthetics of individual leaflets in isolated LM-cell plasma membranes. As measured by decreas...

Microenvironment and Immunology Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

There is a growing interest in the cell–cell communication roles in cancer mediated by secreted vesicles termed exosomes. In this study, we examined whether exosomes produced by cancer cells could transmit information to normal stromal fibroblasts and trigger a cellular response. We found that some cancer-derived exosomes could trigger elevated a-smooth muscle actin expression and other changes...

Changes Alter Fibroblast Responses to Bleomycin-Induced E Prostanoid Receptor

Microenvironment and Immunology Loss of Fibroblast HIF-1a Accelerates Tumorigenesis

Solid tumors consist of malignant cells and associated stromal components, including fibroblastic cells that contribute to tumor growth and progression. Although tumor fibrosis and aberrant vascularization contribute to the hypoxia often found in advanced tumors, the contribution of hypoxic signaling within tumor-associated fibroblasts to tumorigenesis remains unknown. In this study, we used a ...

Abstract 3: Identification of Fibroblast Subtypes during Hypertrophic Scar Development

is the pathologic formation of endochondral bone in soft tissue commonly occurring after severe trauma. HO is a SMAD-signaling dependent process typically occurring in response to an acute inflammatory insult. Traditionally targeted therapeutics for treatment of HO have focused on mesenchymal cell progenitors. However, macrophages which are integral orchestrators of the initial inflammatory res...